Yi Lu, MD, PhD



Call 617-732-6600

Accepting new patients.

As a neurosurgeon-scientist, Dr. Yi Lu's major academic activities are combinations of investigational researches and clinical innovations. His main research contribution is the identification of the essential role of PTEN/mTOR pathway in axon regeneration after spinal cord injury. Dr. Lu's major clinical expertise is minimally invasive, muscle sparing spine surgery technique and its use in decreasing patients’ surgical morbidities. 

Prior to focusing his basic science research on spinal cord injury, Dr. Lu studied the relationship between DNA repair and tumorigenesis during his PhD study. His major contribution during that period was the identification that the disruption of the transcription coupled DNA repair process decreases the chance of tumor formation. He also studies the use of small molecules in blocking transcription coupled DNA repair pathway as a potential therapeutic agent and the role of RNA polymerase II, an important protein in transcription coupled DNA repair pathway, in apoptosis.

During Dr. Lu's post-doc research, he focused his research on the molecular mechanisms of axon regeneration after spinal cord injury. The major achievement during that time is the identification of the importance of PTEN/mTOR pathway in regulating axon regeneration after spinal cord injury. Dr. Lu's research also led to his winning of the American Association of Neurological Surgeons Spinal Cord Injury Research award in 2011. Currently his ongoing research is focused on the use of cell therapy with the combination of axon regeneration to achieve effective functional recovery after severe spinal cord injury.

Dr. Lu's clinical interests are focused on spine surgery, especially minimally invasive spine surgery technique and the use of it to decrease surgical morbidities such as, post-operative pain, iatrogenic destabilization, infection risk, prolonged narcotic use and slow return to work.  Currently he is focusing on further advancing of the minimally invasive, muscle sparing spine surgical techniques, especially for complex spine surgeries such as spinal tumor reconstructive surgery and adult spinal deformity surgeries.

In summary, Dr. Lu's contributions to academic neurosurgery are in the advancement of both spinal cord injury research and minimally invasive spinal surgery.

Hours of Operation

Dr. Lu is located at Mansfield Health Center every 2nd and 4th Thursday of the month. 





Artificial Disc Replacement, Cervical Radiculopathy, Cervical Stenosis, Chiari Malformation, Degenerative Disc Disease, Disc Herniation, Endoscopic Neurosurgery, Image-Guided Surgery, Lumbar Radiculopathy, Lumbar Stenosis, Minimally Invasive Surgery, Muscle Sparing Spine Surgery, Myelopathy, Peripheral Nerve Disease, Scoliosis, Slipped Disc, Spinal Cord Injury, Spinal Cord Tumors, Spinal Deformity, Spinal Disorders, Spinal Fracture Reconstruction, Spinal Fusion, Spine Tumors, Spondylolisthesis


Columbia University of Physicians & Surgeons, Doctor of Medicine Albert Einstein College of Medicine, PhD


Brigham & Women's Hospital, Neurosurgery


Brigham & Women's Hospital, General Surgery

Teaching or Professional Positions

Assistant Professor, Harvard Medical School

Professional Memberships

American Association of Neurological Surgeons

Congress of Neurological Surgeons

Massachusetts Medical Society

American College of Surgeons, Associate Fellow

North American Spine Society